Leukocyte Alkaline Phosphatase (LAP)

It is an isoenzyme of the Alkaline Phosphatase enzyme group, which is also found in immune response group of cells called leukocytes. It is considered as a marker of a cancer type called Chronic Myeloid Leukaemia (CML), which targets leukocytes.
Interpretation:Although the result is needed for the diagnosis of CML, it may also give information about other leukocyte dysfunctions. These include essential thrombocytosis (overproduction of clotting cells called platelets), myelofibrosis with bone marrow destruction, polycythaemia vera characterised by overproduction of erythrocytes (red blood cells) in the bone marrow, aplastic anaemia characterised by decreased erythrocyte production in the bone marrow, pernicious anaemia characterised by a decrease in the number of erythrocytes due to vitamin B12 malabsorption.
Sample: Blood smear
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