HLA (Human Leucocyte Antigen) is the major histocompatibility complex (MHC) in humans.It is a part of the immune system which is controlled by the genes located on Chromosome 6. It encodes cell surface molecules, specialized to present antigenic peptides to T cell receptor on T cells to start immunologic response.They are also responsible of disease defense.They are the major course of organ transplant rejections.There are 3 major and 3 minor Histocompability Complex(MHC) Class I genes in the HLA. These major genes are HLA-A, HLA-B and HLA-C. Minor genes are HLA-e, HLA-F and HLA –G.
Interpretation:HLA B27 is associated with ankylosing spondilitis, psoriatic arthritis, inflamatory bowel disease and reactive arthritis. HLA B-7 is used to distinguish true HLA B27 positives from false results HLA 29 is associated with Birdshot Chorioretinopathy (BSCR) an eye condution in which painless light coloured spots develop on retina HLA B51 is associated with Behcet’s Disease (A vasculitic disorder with the presence of recurrent oral, genital ulcers, eye diseases and skin lesions. HLA DR is associated with matching transplant donors and recipients.
Sample: Arm vein plasma (EDTA). Nonfasting
Working day: Everyday
Result Time: 15 days (Consult the laboratory)
