If antibodies against the body’s beta 2 glycoproteins are detected, thrombophilia (unexpected bleeding) and recurrent miscarriages, called Acute Phospholipid Syndrome (APS) may be observed. These antibodies attact body’s phospholipids. Since these lipids are found in the cell membrane, especially in the platelet (thrombocyte) membranes, unexpected bleeding becomes inevitable. IgM type antibodie are detected in acute period, then they leave their place to IgG type antibodies. Beta 1 Glycoprotein antibodies bind to anionic (negatively charged) phospholipids. This feature is important in diagnosing of APS. Because while B1 Glycoproteins disrupt the cell membrane structure, Beta 2 Glycoproteins bind to signal proteins in the cell membrane, interrupting cellular communication and triggering the thrombolytic effect. Understanding this mechanism, also affects the treatment protocol.
They are antibodies of Beta 2 Glycoprotein which IgA is the first synthesized type followed by IgM and finally IgG.
Interpretation:These antibodies may be the reason for a prolonged Lupus Erythromatosis disease.
Sample: Arm venous blood. Nonfasting
Working day: Tuesday
Result Time: Next day at 6 PM
