Causes of fatigue arise when the body is unable to produce sufficient energy or fails to use the produced energy efficiently. It manifests with symptoms such as exhaustion, muscle weakness, and lack of motivation. The most common causes of fatigue include sleep disorders, stress, unhealthy eating habits, and a sedentary lifestyle. A body that does not get adequate rest may struggle to generate the necessary energy to carry out daily activities. Similarly, an unbalanced diet that lacks essential vitamins and minerals can lead to persistent fatigue.
Causes of fatigue also include chronic diseases, hormonal imbalances, and psychological factors. Conditions such as iron deficiency anemia, thyroid disorders, and diabetes negatively impact energy production, causing individuals to feel depleted. Psychological factors like depression and anxiety disorders also play a role in fatigue. Moreover, prolonged stress increases cortisol levels in the body, weakens the immune system, and may lead to chronic fatigue. Identifying the underlying cause of fatigue requires consulting a healthcare professional and making necessary lifestyle changes.
Possible Causes of Fatigue
- Inadequate and unbalanced nutrition
- Insufficient water intake (dehydration)
- Irregular sleep patterns and poor sleep quality
- Excessive caffeine or alcohol consumption
- Sedentary lifestyle and lack of exercise
- Anemia (Iron deficiency, Vitamin B12 deficiency)
- Thyroid disorders (Hypothyroidism or hyperthyroidism)
- Infectious diseases (Influenza, common cold, COVID-19, etc.)
- Chronic diseases (Diabetes, kidney failure, heart diseases)
- Blood sugar imbalances
- Vitamin and mineral deficiencies (Vitamin D, magnesium, zinc)
- Allergic reactions and immune system disorders
- Stress and anxiety
- Depression
- Post-traumatic stress disorder (PTSD)
- Emotional exhaustion (Burnout syndrome)
- Menopause and hormonal changes
- Adrenal insufficiency (Addison’s disease)
- Hypoglycemia (Low blood sugar levels)
- Sleep medications, antidepressants, and certain painkillers
- Excessive antibiotic use and disruption of gut microbiota
- Heavy smoking or substance abuse
- Heavy metal poisoning (Lead, mercury, etc.)
- Post-surgical fatigue and recovery process
- Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)

What Are the Causes of Persistent Fatigue?
Symptoms such as excessive daytime sleepiness, leg weakness, and lack of energy are common indicators of persistent fatigue. Although fatigue is a condition that everyone experiences occasionally, its persistence may signal an underlying health issue.
Inadequate nutrition, sleep disorders, vitamin deficiencies, and chronic illnesses are among the primary causes of fatigue. When the body does not receive adequate rest and proper nutrients, energy production decreases, leading to both physical and mental exhaustion.
Leg weakness, in particular, can make daily movements difficult and reduce quality of life. Neurological disorders, muscle loss, and circulation problems may contribute to this condition. When sufficient oxygen and nutrients fail to reach the muscles, weakness can occur. Similarly, leg numbness may be due to circulatory issues or nerve compression. Neurological diseases such as diabetes and multiple sclerosis may also cause these symptoms.
Generalized body weakness may indicate a weakened immune system and inadequate muscle function. Muscle loss may result from low protein intake or a sedentary lifestyle. Additionally, hormonal imbalances can lead to both muscle weakness and fatigue.
Persistent fatigue can stem from both psychological and physical factors. Stress, anxiety disorders, and depression can negatively affect the body, leading to a constant feeling of fatigue. If fatigue persists for an extended period, consulting a healthcare professional and undergoing necessary medical tests is the best approach.

Causes of Post-Surgical Fatigue
Post-surgical fatigue is an inevitable condition for many patients. During the recovery period, the body expends increased energy, and certain systems must work harder than usual. Several factors contribute to post-operative fatigue, including the magnitude of the surgery, the effects of anesthesia, nutritional deficiencies, and the risk of infections, all of which can cause a decline in energy levels.
The duration of post-surgical fatigue varies from person to person, with most patients recovering within a few weeks. However, in some cases, fatigue may persist longer and indicate an underlying medical issue.
One of the most common causes of fatigue after surgery is infection. As the body fights infection, the immune system consumes extra energy, leading to excessive fatigue. Symptoms of infection include fever, chills, redness, and pain at the surgical site. In such cases, seeking immediate medical attention is crucial.
Why Does Post-Surgical Fatigue Occur?
One of the primary causes of post-operative fatigue is blood loss during and after surgery. Blood loss reduces oxygen delivery to tissues, and when the body fails to generate sufficient energy, fatigue ensues. Additionally, prolonged immobility following surgery can lead to muscle weakness, making patients feel even more exhausted.
Thyroid disorders can also contribute to prolonged post-surgical fatigue. If the thyroid gland does not produce enough hormones, metabolism slows down, causing persistent tiredness. Therefore, individuals experiencing prolonged post-surgical fatigue should undergo thyroid function tests.
If post-surgical fatigue is severe or long-lasting, consulting a doctor is essential to rule out any underlying complications.