Secretin

Secretin is a digestive hormone secreted by the wall of the upper part of the small intestine (duodenum), that regulates gastric acid secretion and pH levels in the duodenum. When gastric acid secretes hydrochloric acid and passed into the intestine, secretin is released into the bloodstream to stimulate pancreatic duct cells to release water and bicarbonate. This mechanism protects intestinal lining against acidic damage by neutralising hydrochloric acid. Secretin also inhibits secretion of Gastrin from the stomach to stop releasing HCl.
Interpretation: Hypersecretinemia (above normal) may be seen in duodenal ulcers and advanced renal failure and in sone pancreatic tumors secreting ectopic (unusual) hormones and Zollinger–Ellison’s Syndrome (a rare digestive tumor seen in small intestines, pancreas or both). Hyposecretinemia (below normal) may indicate untreated celiac disease or aclorhydria (absence of hydrochloric acid in gastric secretion).
Sample: Arm vein blood. Fasting
Working day: Tuesday
Result Time: Consult the laboratory.