Although Rubella virus has been eliminated widely in the World, ongoing Rubella virus activity in many countries are stil la problem for pregnancy. Congenital Rubella Syndrome(CRS), which may occur when a woman is infected by Rubella Virus during her pregnancy. If a pregnant woman gets the virus, first ımmunglobulin to react is IgM. The incubation period of the virus is after 14-23 days of the contamination. It is contaminated by a close contact with a person with acute infection . The symptom is fever and skin rashes, the contamination may have occured 4-7 days before the symptoms. IgM result shows the primary infection and stays in blood for 7-10 days as Ig G starts to appear. If IgM and IgG are both positive, it is necessary to perform an Avidity test to predict the possible contamination period. Avidity test is a qualitative test to differentiate between primary and nonprimary infection. Antibody avidity(the strength of binding between the antigen and antibody), increases with time. As the maturation of immune response increases, low avidity antibodies are replaced with high avidity antibodies. In acute Rubella infection, low avidity lasts up to 3 months after the appearance of IgG antibodies. This result means that, if the antibodies have low binding strength, the infection is primary, because the avidity increases over time. If the avidity is high, this means the infection was a long term infection.
Interpretation: Rubella infection is very important in pregnancies. The consequences for the unborn child may be severe, especially if the infection is in the 12 weeks of pregnancy. The resultant possibilities are,growth delays, cataracts, deafness, congenital heart defects, organ defects, intellectual disabilities.
Sample: Arm vein blood.Nonfasting
Working day: Everyday
Result Time: Same day 6:00 PM
