It is a compound involved in local immune responses as well as regulating the functions in the gut and acting as a neurotransmmitter for the brain, spinal chord and uterus. Most histamine in the body is in mast cell granules and white blood cells (leucocytes) called basophils. At sites of potential injury, histamine release is immunologic. The mast cells are sensitized by IgE which is attached to their membranes and release histamine. Histamine binds to a G Protein coupled with histamine receptors and drops blood pressure by vascular hyperpermeability, synthesis of vascular smooth muscle relaxants such as nitric oxide and other compounds which cause blood vessel dilation. These all lead to classic symptoms of an allergic reaction.
Interpretation: Due to its functions in allergy and neurotransmitting its rise results in headaches or migraines, nasal congestion or sinus issues, fatique, hives,digestive issues, irregular menstrual cycle, nausea and vomitting.
Sample: Arm vein plasma (EDTA). Nonfasting
Working day: Tuesday
Result Time: 30 days (Consult the laboratory)