Cold Agglutinins

Cold agglutinin disease (CAH) is caused by autoantibodies formed against the T protein in erythrocytes that cause autoimmune haemolytic anaemia, which leads to the breakdown of erythrocytes below normal body temperature. The presence of cold agglutinins may also indicate other diseases. They can also be caused by other autoimmune and lymphoprolative diseases (a very rare genetic autoimmune disease), M.Pneumoniae and Ebstein Barr Virus, HIV, Influenza virus and Brucella virus.
Interpretation:In this disease, damaged erythrocytes are haemolysed (broken down). Erythrocyte and haematocrit values decrease, MCV (erythrocytes create more volume than normal in order to carry more oxygen), MCH (haemoglobin in erythrocytes) and MCHC (the ratio of haemoglobin in erythrocytes to total erythrocyte amount independent of erythrocyte volume) increase above normal.
Sample: Arm venous blood. Nonfasting
Working day: Everyday
Result Time: Next day at 6 PM