CK Isoenzymes

Creatinine Kinase (CK) is the enzyme that catalyzes transfer of phosphate from high energy phosphate donating molecules (Adenosine Triphosphate-ATP) to spesific substrate(acceptor) molecules, thus playing an important role in energy metabolism. CK has three isoenzymes. These are, CK-MM, CK-MB and CK-BB. CK-MM is spesific to skeletal muscle, CK-MB is spesific to myocardial muscle and CK-BB is spesific to brain and lungs. When any of these tissues are damaged, they are released in blood.
Interpretation: If CK is found high in blood and no kidney failure is diagnosed, an overproduction is suspected. This test is done to specify the site of the overproduction. CK-BB (CPK 1), is mostly found in brain and lungs therefore, this elevation may be due to a brain cancer, brain injury, electroconvulsive therapy, pulmonary infarction and seizure. CK-MB (CPK 2) levels rise in 3-6 hours after the heart attack. The level peaks at 12-24 hours and returns to normal 12-48 hours after tissue death. It also increases in electrical injuries, heart defibrillation (purposeful medical heart shocking), inflammation of the heart muscle(myocarditis) and open heart surgery. CK-MM (CPK 3) elevation, may be due to a muscle injury or muscle stress. These may be crush injuries, muscle damage caused by drugs, muscular dystrophy, myositis (skeletal muscle inflamation), too many intramuscular injections, nerve and muscle function testing (electromyography-EMG), recent seizures, recent surgery and strenous exercise.
Sample: Arm vein blood. Nonfasting
Working day: Consult the laboratory
Result Time: Consult the laboratory